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Книга представляет собой обзор данных, собранных Научным комитетом по действию атомной радиации при ООН за 30 лет его деятельности. Рассмотрены вопросы влияния радиации на жизнедеятельность, предельно допустимые дозы, а также наблюдаемые уровни радиоактивности в окружающей среде и продуктах питания (по отдельным регионам).
Книга рассчитана на широкий круг читателей.

Рассматриваются первичные радиогенетические эффекты и отдаленные генетические последствия облучения. Приводятся литературные и собственные экспериментальные данные о возможности защиты организмов и популяций от однократного и длительного (на протяжении десятка поколений) воздействия ионизирующей радиации. Обсуждается проблема адаптации популяций к облучению в малых дозах.
Для генетиков, радиобиологов, медиков.

Radioisotope therapy is an internal form of radiation used to treat cancer; it may be administered orally or intravenously and represents the nearest treatment option to the 'magic bullet', specifically targeting sites of disease whilst sparing surrounding normal tissues. Radioisotope therapy has an important role to play in modern medicine, particularly in the treatment of thyroid disease, neuroendocrine tumours, bone metastasis and non-Hodgkin's lymphoma. It is found in both the diagnostic setting and in therapy, but recently there has been a renaissance in the application of radioisotope unsealed sources in therapeutic indications. It is an active area of research, with the quest for new compounds that will be specific for therapeutic targets. This book is an essential, practical guide to the use of radioisotope therapy, and also includes the background and developmental biology which underpins its use. Individual tumours and diseases are explored, with specific focus given to radioisotope treatment options. The barriers to radioisotope therapy, such as ease of access, acquisition of radioisotopes, radiation protection regulations, and cost are also discussed. ABOUT THE SERIES Radiotherapy remains the major non-surgical treatment modality for the management of malignant disease, with over 50% of patients receiving treatment at some time during the management of their malignant disease. It is based on the application of the principles of applied physics, radiobiology, and tumour biology to clinical practice. Each volume in this series takes the reader through the basic principles of different types of radiotherapy, and then develops these by individual sites. This series of practical handbooks are aimed at physicians both training and practising in radiotherapy, as well as medical physicists, dosimetrists, radiographers and senior nurses.

Answering the need that exists for a single reference to address the practical issues of implementing image guided radiation therapy (IGRT) into prostate cancer treatment.

Radiation and the effects of radioactivity have been known for more than 100 years. International research spanning this period has yielded a great deal of information about radiation and its biological effects and this activity has resulted in the discovery of many applications in medicine and industry including cancer therapy, medical diagnostics, and quality control during manufacturing. After Chernobyl, there has been a tendency to regard radiation as harmful, even in situations where the doses are equal to or below the natural level. Radiation and Health presents a balanced view of the nature of radiation and its existence in the environment, as well as discussing its effects on plants, animals and humans. It also provides a survey of knowledge to date, from the discovery and basic theory of radiation and radioactivity to more recent developments concerned with the nature of radiation and its effect on biological systems. Numerous examples, exercises, and diagrams are included to make this book accessible to non-specialists. Radiation and Health provides information about the uses and consequences of ionizing radiation in medicine, research, and industry. It offers a basis for applying some basic calculations and comparing the results, and identifies risk factors to help establish rules and regulations that limit radiation doses, both to the individual and to society.

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. The expanding array of new targeting molecules (recombinant antibodies or peptides) may increase the therapeutic efficacy. The title of this book "Targeted Radionuclide Tumor Therapy – Biological aspects" was selected to reinforce the concept that a major focus was devoted to understanding the biological effects of targeting and radiation. Furthermore, our rapidly expanding knowledge of low dose-rate effects, different types of cell death, autosensitization and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.
The development of targeted therapy is a true multidisciplinary enterprise involving physician scientists from the fields of nuclear medicine, radiation therapy, diagnostic radiology, surgery, gynaecology, pathology and medical oncology/haematology. It also involves many preclinical scientists working with experimental animal models, immunochemistry, recombinant antibody technologies, radiochemistry, radiation physics and basic cell biology.
It is the ambition of the editors to enable deeper insights in the process of improving targeted therapy. We believe that the time now has come when targeted therapy can soon be added to standard oncology treatment regimens.

Essential Nuclear Medicine Physics provides an excellent introduction to the basic concepts of the daunting area of nuclear physics. Logically structured and clearly written, this is the book of choice for anyone entering the field of nuclear medicine, including nuclear medicine residents and fellows, cardiac nuclear medicine fellows and nuclear medicine technology students. The text is also a handy quick-reference guide for those already working in the field of nuclear physics.

This new edition provides a basic introduction to nuclear physics and the interactions of radiation and matter. The authors also provide comprehensive coverage of instrumentation and imaging, with separate chapters devoted to SPECT, PET, and PET/CT. Discussion of radiation biology, radiation safety and care of victims of radiation accidents completes the text, with an appendix containing the latest NRC rules and regulations.

Essential Nuclear Medicine Physics presents difficult concepts clearly and concisely, defines all terminology for the reader, and facilitates learning through extensive illustrations and self-assessment questions.

The approaches originally suggested in NCRP Report No. 37, Precautions in the Management of Patients Who Have Received Therapeutic Amounts of Radionuclides (1970), are incorporated and updated. This Report makes recommendations on explaining risks from therapeutic procedures and obtaining adequate, informed patient consent; dose limits for members of the patient's family; patient confinement in a hospital or skilled-care facility; and patient records including the radionuclide and activity used, the treating physician, and contact information. Section 1 of Report No. 155 is an introduction and includes some brief historical items. This Section discusses the basic principles of both radiopharmaceutical therapy and brachytherapy. Section 2 deals with basic radiation safety principles in a medical facility and includes a description of the radiation safety program, dose limits, staffing and definitions specific to this Report. Section 3 addresses radiopharmaceutical therapy including both clinical and radiation safety aspects. Appendices A and B expand on the patient release criteria outlined in Section 3 and include a spreadsheet program for assisting in determining patient release instructions. Section 4 deals specifically with brachytherapy including techniques, terminology, and a brief discussion of applicable dosimetry. Section 5 includes facility design for both nuclear-medicine and radiation-oncology installations. Section 6 describes changes in patients' status, including medical emergencies and includes guidelines for other situations that may be adapted to readers' facilities. Appendix C presents a discussion of quality-assurance requirements for high dose rate afterloading which is an increasingly useful modality. Appendix D outlines shielding requirements for high dose rate brachytherapy installations.

Using a multidisciplinary approach that combines physics, biology, medicine, risk assessment, and engineering, Bioeffects and Therapeutic Applications of Electromagnetic Energy presents detailed descriptions of fundamental physical concepts and principles in electromagnetic fields and radiation. The book provides a review of cutting-edge research in EM health effects and EM therapy along with emerging areas of bioengineering and biomedical engineering. Several chapters address standards and regulatory issues related to EM human exposure. This comprehensive text also offers coverage of bioeffects as well as risk assessment of low frequency fields and radio frequency radiation.

From the Foreword…
The past two decades have provided an opportunity for investigators to explore the capacity of monoclonal antibodies and other targeting molecules to deliver therapeutic doses of radiation via radioisotope conjugates. This book assembles a strong cast of these investigators to review the progress that has been made and to clarify the challenges that remain.
-Albert F. Lobuglio, M.D.
Director, Comprehensive Cancer Center
Associate Dean, School of Medicine
Evalina B. Spencer Professor of Oncology
University of Alabama at Birmingham
...a clear, complete and outstanding report of the current status of radioimunotherapy....
...highly recommended to nuclear medicine residents, but it also serves a solid review of radioimmunotherapy for physicians who have been in this field for many years.
-Tijdschrift voor Nucleaire Geneeskunde, 2000
…collects different contributions from the most important investigators in the field….
…important….very sharp and interesting.
-Minerva Medica

Описание: Разгледжаны асноўныя ўласцівасці выпраменьвання і працэсы іх узаемаадносін з навакольным асяроддзем; дазіметрычныя велічыні радыеактыўнасці і адзінкі іх вымярэння; прылады і метады кантролю радыеактыўнага забруджвання вонкавага асяроддзя; пытанні ўплыву радыяцыі на арганізм чалавека; гігіенічныя аспекты радыяцыйнай бяспекі насельніцтва (нормы і правілы бяспекі, асабліва ў раёнах, забруджаных пасля аварыі на ЧАЭС); асноўныя дозавыя межы апраменьвання і іх дапушчальныя ўзроўні; санітарныя нормы работы з крыніцамі іанізуючых выпраменьванняў і г. д. Прыведзены даныя аб ліквідацыі радыяцыйных вынікаў аварыі на Чарнобыльскай АЭС.